Can I consume collagen if I have a histamine intolerance or mast cell activation?

If you have a known histamine intolerance or mast cell activation, consuming collagen may not be appropriate for you. Collagen is high in the amino acid hydroxyproline, which once digested can be converted into oxalates, a naturally-occurring compound that can trigger the release of mast cells. Although this isn't an issue for individuals without this rare condition, it can cause adverse reactions in people who have a histamine intolerance or mast cell activation.